Miko Yotsuya's eyes water as she fixates on a single spot on her phone—she ignores yet another dreadful, horrific monster that is in her face, uttering the disturbing words: "Can you see me?" Before now, Miko enjoyed her unassuming high school days, with late-night horror shows serving only as a form of entertainment. But ever since one fateful day, she is the only person aware of the invisible monsters walking freely among humans. Courageously, Miko makes a bold decision: she will never, under any condition, acknowledge the presence of the horrid specters. However, even though she pretends they do not exist, she can still see how they disturb the people around her, especially her best friend, the energetic and lovely Hana Yurikawa. In order to protect them from the monsters' annoyances, Miko gives it her best to continue her school life and avoid every troublesome crisis—even when they scare her to tears. Miko is a typical high school student whose life turns upside down when she suddenly starts to see gruesome and hideous monsters. Despite being completely terrified, Miko carries on with her daily life, pretending not to notice the horrors that surround her. She must endure the fear in order to keep herself and her friend Hana out of danger, even if that means coming face to face with the absolute worst. Blending both comedy and horror, Mieruko-chan tells the story of a girl who tries to deal with the paranormal by acting indifferent toward it.