Struggling yet brilliant 19-year-old Minato Sahashi has failed his college entrance exams for the second time, resulting in him being regarded as worthless by those around him. However, the course of his seemingly bleak future is altered dramatically when a beautiful, supernatural woman falls from the sky and into his life. That woman, Musubi, is a unique being known as a "Sekirei," a humanoid extraterrestrial with extraordinary abilities. These aliens are known for kissing humans carrying the Ashikabi gene in order to awaken additional latent powers deep within. Recognizing the potential within the seemingly insignificant youth, Musubi kisses the bewildered Minato, initiating a bond between the two of them. This drags him into the high-stakes world of the Sekirei, where he and his new partner must compete against others in a battle for survival called the "Sekirei Plan." However, unbeknownst to the contestants, there is far more at risk that what the competition initially entailed. Minato Sahashi is extremely intelligent, yet due to his inability to cope under pressure has failed the college entrance exam twice. As a result he has been branded an idiot and loser by many. One day after talking to his yet again disappointed mother he comes into contact with a girl named Musubi who was under attack. The girl runs but takes him with her and soon finds that Minato, while unknown to him, is an Ashikabi, one of the mysterious set of masters that have the genetic trait that can become partners with some of the 108 cute girls, buxom women, and bish?nen called “Sekirei”. The reason for the partnership allows the Sekirei to use all their power to win in the competition held by the mysterious MBI corporation.